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| Spider-Physiology: Itsy Bitsy possesses eight limbs, six eyes, and chelicerae in her mouth. She also has only three fingers on each hand. |
| Wall-Crawling: Itsy Bitsy can adhere to vertical and upside down surfaces. |
| Organic Webbing: The body of Itsy Bitsy produces organic webbing with sharp edges. |
| Regeneration: Itsy Bitsy possesses a healing factor on par with Deadpool's, being able to quickly heal from fractures and even start growing back her hands the second after they were cut off. |
| Spider-Sense: Itsy Bitsy possesses an extrasensory "danger" or "spider" sense which warns her of potential immediate danger by the manifestation of a tingling sensation in the back of her skull, and links with her superhuman kinesthetics, enabling her to evade most any injuries, unless she cognitively overrides her automatic reflexes. |
| Corrosive Spit: The mouth of Itsy Bitsy can generate a corrosive substance capable of disintegrating clothes on contact. |
| Dual Swords: Similarly to Deadpool, Itsy Bitsy employs a pair of swords for combat. |
| Firearms: Itsy Bitsy also wields a small automatic gun. |
